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Centre for New Antivirals and Antineoplastics
Suported by the Ministry of Education, Czech Republic
 Centre for New Antivirals and Antineoplastics
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Publications List of Publications 2011

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212. Dejmek, M.; Hřebabecký, H.; Dračínský, M.; Neyts, J.; Leyssen, P.; Mertlíková-Kaiserová, H.; Nencka, R.: "Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxanorbornane and their antiviral properties" Collect. Czech. Chem. Commun. 2011, 76, 1549-1566.
211. Dejmek, M.; Hřebabecký, H.; Šála, M.; Dračínský, M.; Nencka, R.: "Microwave-Assisted Solvent-Free Diels-Alder Reaction - A Fast and Simple Route to Various 5,6-Substituted Norbornenes and Polychlorinated Norbornenes" Synthesis 2011, 24, 4077-4083.
210. Šála, M.; De Palma, A. M.; Hřebabecký, H.; Dejmek, M.; Dračínský, M.; Leyssen, P.; Neyts, J.; Mertlíková-Kaiserová, H.; Nencka, R.: "SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors" Bioorg. Med. Chem. Lett. 2011, 21, 4271-4275.
209. Mertlíková-Kaiserová, H.; Rumlová, M.; Tloušťová, E.; Procházková, E.; Holý, A.; Votruba, I.: "Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG" Biochem. Pharmacol. 2011, 82, 131-138.
208. Matoušová, M.; Votruba, I.; Otmar, M.; Tloušťová, E.; Günterová, J.; Mertlíková-Kaiserová, H.: "2´-Deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential" Epigenetics 2011, 6, 769-776.
207. Jansa, P.; Baszczyňski, O.; Dračínský, M.; Votruba, I.; Zídek, Z.; Bahador, G.; Stepan, G.; Cihlar, T.; Mackman, R.; Holý, A.; Janeba, Z.: "A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities" Eur. J. Med. Chem. 2011, 46, 3748-3754.
206. Břehová, P.; Česnek, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction" Tetrahedron 2011, 67, 7379-7385.
205. Jansa, P.; Špaček, P.; Votruba, I.; Břehová, P.; Dračínský, M.; Klepetářová, B.; Janeba, Z.: "Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol" Collect. Czech. Chem. Commun. 2011, 76, 1121-1131.
204. Jersey, J.; Holý, A.; Hocková, D.; Naesens, L.; Keough, D. T.; Guddat, L. W.: "6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs" Curr. Top. Med. Chem. 2011, 11, 2085-2102.
203. Hocková, D.; Holý, A.; Andrei, G.; Snoeck, R.; Balzarini, J.: "Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity" Bioorg. Med. Chem. 2011, 19, 4445-4453.
202. Jansa, P.; Holý, A.; Dračínský, M.; Baszczyňski, O.; Česnek, M.; Janeba, Z.: "Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction" Green Chem. 2011, 13, 882-888.
201. Sedláček, O.; Břehová, P.; Pohl, R.; Holý, A.; Janeba, Z.: "The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions" Can. J. Chem. 2011, 89, 488-498.
200. Baszczyňski, O.; Jansa, P.; Dračínský, M.; Klepetářová, B.; Holý, A.; Votruba, I.; De Clercq, E.; Balzarini, J.; Janeba, Z.: "Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines" Bioorg. Med. Chem. 2011, 19, 2114-2124.
199. Dračínský, M.; Jansa, P.; Ahonen, K.; Buděšínský, M.: "Tautomerism and the Protonation/Deprotonation of Isocytosine in Liquid- and Solid-States Studied by NMR Spectroscopy and Theoretical Calculations" Eur. J. Org. Chem. 2011, 8, 1544-1551.
198. Dračínský, M.; Jansa, P.; Chocholoušová, J.; Vacek, J.; Kovačková, S.; Holý, A.: "Mechanism of the isotopic exchange reaction of the 5-H hydrogen of uracil derivatives in water and nonprotic solvents" Eur. J. Org. Chem. 2011, 4, 777-785.
197. Čechová, L.; Jansa, P.; Šála, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines" Tetrahedron 2011, 67, 866-871.
196. Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: "Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498–5507.
195. Nauš, P.; Perlíková, P.; Pohl, R.; Hocek, M.: "Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2'-C-methylribonucleosides, arabinonucleosides and 2'-deoxy-2'-fluoroarabinonucleosides" Collect. Czech. Chem. Commun. 2011, 76, 957-988.
194. Tichý, T.; Andrei, G.; Dračínský, M.; Holý, A.; Balzarini, J.; Snoeck, R.; Krečmerová, M.: "New prodrugs of Adefovir and Cidofovir" Bioorg. Med. Chem. 2011, 19, 3527-3539.
193. Topalis, D.; Lebeau, I.; Krečmerová, M.; Andrei, G.; Snoeck, R.: "Activity of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells" Antimicrob. Agents Chemother. 2011, 55, 1961-1967.
192. Otmar, M; Dračínský, M.; Krečmerová, M.; Balzarini, J.; Andrei, G; Snoeck, R.: "Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine" Heterocycles 2011, 84, 797-813.
191. Mařák, D.; Otmar, M.; Votruba, I.; Dračínský, M.; Krečmerová, M.: "8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2011, 21, 652-654.
190. Perlíková, P.; P.; Pohl, R.; Votruba, I.; Shih, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides" Bioorg. Med. Chem. 2011, 19, 229-242.