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Centre for New Antivirals and Antineoplastics
Suported by the Ministry of Education, Czech Republic
 Centre for New Antivirals and Antineoplastics
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Publications List of Publications 2010

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189. Krečmerová, M.; Holý, A.; Andrei, G.; Pomeisl, K.; Tichý, T.; Břehová, P.; Masojídková, M.; Dračínský, M.; Pohl, R.; Laflamme, G.; Naesens, L.; Hui, H.; Cihlar, T.; Neyts, J.; De Clercq, E.; Balzarini, J.; Snoeck, R.: "Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents" J. Med. Chem. 2010, 53, 6825-6837.
188. Elbert, T.; Břehová, P.; Holý, A.: "The preparation of 3H-labeled acyclic nucleoside phosphonates and study of their stability" Collect. Czech. Chem. Commun. 2010, 75, 757-766.
187. Janeba, Z.; Holý, A.; Pohl, R.; Snoeck, R.; Andrei, G.; De Clercq, E.; Balzarini, J.: "Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base" Can. J. Chem. 2010, 88, 628-638.
186. Hocková, D.; Dračínský, M.; Holý, A.: "Synthesis and properties of a novel type of acyclic nucleoside phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic acids" Eur. J. Org. Chem. 2010, 2885-2892.
185. Hoffman, H.E.; Jiraskova, J.; Zvelebil, M.; Konvalinka, J.: "Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity" Collect. Czech. Chem. Commun. 2010, 5, 59-79.
184. Fanfrlik, J.; Bronowska, A.K.; Rezac, J.; Prenosil, O.; Konvalinka, J.; Hobza, P.: "A Reliable Docking/Scoring Scheme Based on the Semiempirical Quantum Mechanical PM6-DH2 Method Accurately Covering Dispersion and H-Bonding: HIV-1 Protease with 22 Ligands" J. Phys. Chem. B. 2010, 114, 12666-12678.
183. Zabransky, A.; Hoboth, P.; Hadravová, R.; Stokrova, J.; Sakalian, M.; Pichová, I.: "The noncanonical Gag domains p8 and n are critical for assembly and release of mouse mammary tumor virus" J. Virol. 2010, 84, 11555-11559.
182. Bohmová, K.; Hadravová, R.; Stokrova, J.; Tuma, R.; Ruml, T.; Pichová, I.; Rumlová, M.: "The effect of dimerizing domains and basic residues on in vitro and in vivo assembly of Mason-Pfizer monkey virus and Human immunodeficiency virus" J. Virol. 2010, 84, 1977-1988.
181. Krečmerová, M.; Holý, A.; Andrei, G.; Pomeisl, K.; Tichý, T.; Břehová, P.; Masojídková, M.; Dračínský, M.; Pohl, R.; Laflamme, G.; Naesens, L.; Hui, H.; Cihlar, T.; Neyts, J.; De Clercq, E.; Balzarini, J.; Snoeck, R.: "Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents" J. Med. Chem. 2010, 53, 6825-6837.
180. Huerfano, S.; Žíla, V.; Bouřa, E.; Španielová, H.; Štokrová, J.; Forstová, J.: "Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection" FEBS Journal 2010, 277, 1270-1283.
179. Betík, R.; Herrmann, P.; Kotora, M.: "Synthesis of an (±)-Estrone Precursor: the Scope of Zr- and Co-mediated Cycloannulations" Eur. J. Org. Chem. 2010, 646-655.
178. Novotný, J.; Hrabálek, A.; Vávrová, K.: "Synthesis and Structure-Activity Relationships of Skin Ceramides" Curr. Med. Chem. 2010, 17, 2301-2324.
177. Novotný, M.; Hrabálek, A.; Janůšová, B.; Novotný, J.; Vávrová, K.: "Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation" Bioorg. Med. Chem. Lett. 2010, 20, 2726-2728.
176. Myles, L.; Gore, R.; Špulák, M.; Gathergood, N.; Connon, S. J.: "Highly recyclable, imidazolium derived ionic liquids of low antimicrobial and antifungal toxicity: A new strategy for acid catalysis" Green Chem. 2010, 12, 1157-1162.
175. Schiller, R.; Tichotová, L.; Pavlík, J.; Buchta, V.; Melichar, B.; Votruba, I.; Kuneš, J.; Špulák, M.; Pour, M.: "3,5-Disubstituted pyranone analogues of highly antifungally active furanones: Conversion of biological effect from antifungal to cytostatic" Bioorg. Med. Chem. Lett. 2010, 20, 7358-7360.
174. Nencka, R.; Hřebabecký, H.; Dračínský, M.: "Model synthesis of six-membered carbocyclic spironucleosides" Collect. Czech. Chem. Commun. 2010, 75, 1259-1272.
173. Nencka, R.; Šála, M.; Dejmek, M.; Dračínský, M.; Holý, A.; Hřebabecký, H.: "Two convergent approaches toward novel carbocyclic C-nucleosides" Synthesis 2010, 4119-4130.
172. Šála, M.; De Palma, A. M.; Hřebabecký, H.; Nencka, R.; Dračínský, M.; Leyssen, P.; Neyts, J.; Holý, A.: "Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors" Bioorg. Med. Chem. 2010, 18, 4374-4384.
171. Šála, M.; Hřebabecký, H.; Dračínský, M.; Masojídková, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene" Collect. Czech. Chem. Commun. 2010, 75, 1-20.
170. Votruba, I.; Trýznová, J.; Břehová, P.; Tloušťová, E.; Horská, K.; Fanfrlík, J.; Přenosil, O.; Holý, A.: "Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners" Collect. Czech. Chem. Commun. 2010, 75, 1249-1257.
169. Opekar, S.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.; Kotora, M.: "[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes" Heterocycles 2010, 82, 895-907.
168. Šenel, P.; Tichotová, L.; Votruba, I.; Buchta, V.; Špulák, M.; Kuneš, J.; Nobilis, M.; Krenk, O.; Pour, M.: "Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives" Bioorg. Med. Chem. 2010, 18, 1988-2000.
167. Hájek, M.; Cvilink, V.; Votruba, I.; Holý, A.; Mertlíková-Kaiserová, H.: "Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP" Eur. J. Pharmacol. 2010, 643, 6-12.
166. Mertlíková-Kaiserová, H.; Votruba, I.; Matoušová, M.; Holý, A.; Hájek, M.: "Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells" Anticancer Res. 2010, 30, 2791-2798.
165. Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases" ChemMedChem 2010, 5, 1386-1396.
164. Krečmerová, M.; Masojídková, M.; Holý, A.: "Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position" Bioorg. Med. Chem. 2010, 18, 387-395.
163. Keough, D.T.; Hocková, D.; Krečmerová, M.; Česnek, M.; Holý, A.; Naesens, L.; Brereton, I.M.; Winzor, D.J.; de Jersey, J.; Guddat, L.W.: "Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy" Mol. Biochem. Parasitol. 2010, 173, 165-169.
162. Hasník, Z.; Pohl, R.; Hocek, M.: "Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides" Tetrahedron Lett. 2010, 51, 2464-2466.
161. Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkus, G.; Wang, T.; Ray, A.S.; Mackman, R.; Cihlar, T.; Hocek, M.: "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460–470.
160. Bobula, T.; Hocek, M.; Kotora, M.: "Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides" Tetrahedron 2010, 66, 530-536.