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Centre for New Antivirals and Antineoplastics
Suported by the Ministry of Education, Czech Republic
 Centre for New Antivirals and Antineoplastics
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Publications List of Publications 2009

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159. Hrusková, V.; Morávková, A.; Babiarová, K.; Ludvíková, V.; Fricl, J.; Vonka, V.; Forstová, J.: "Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles" Int. J. Oncol. 2009, 35, 1247-1256.
158. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides" Arch. Biochem. Biophys. 2009, 488, 153-162.
157. Macek, P.; Chmelík, J.; Křížová, I.; Kadeřávek, P.; Padrtal, P.; Žídek, L.; Wildová, M.; Hadravová, R.; Chaloupková, R.; Pichová, I.; Ruml, T.; Rumlová, M.; Sklenář, V.: "NMR Structure of the N-Terminal Domain of Capsid Protein from the Mason–Pfizer Monkey Virus" J. Mol. Biol. 2009, 392, 100-114.
156. Kohoutová, Z.; Rumlová, M.; Andreánsky, M.; Sakalian, M.; Hunter, E.; Pichová, I.; Ruml, T.: "The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus" Virology 2009, 384, 59-68.
155. Zábranský, A.; Hadravová, R.; Štokrová, J.; Sakalian, M.; Pichová, I.: "Premature processing of mouse mammary tumor virus Gag polyprotein impairs intracellular capsid assembly" Virology 2009, 384, 33-37.
154. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "The strand transfer oligonucleotide inhibitors of HIV-integrase" J. Enzym. Inhib. Med. Ch. 2009, 24, 241-246.
153. Zídek, Z.; Anzenbacher, P.; Kmoníčková, E.: "Current status and challenges of cytokine pharmacology" Brit. J. Pharmacol. 2009, 157, 342-361.
152. Vaněk, V.; Buděšínský, M.; Kabeleová, P.; Šanda, M.; Kožíšek, M.; Hančlová, I.; Mládková, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiráček, J.: "Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase" J. Med. Chem. 2009, 52, 3652-3665.
151. Pokorna, J.; Machala, L.; Rezacova, P.; Konvalinka, J.: "Current and Novel Inhibitors of HIV Protease" Viruses 2009, 1, 1209-1239.
150. Mlčochová, P.; Bařinka, P.; Tykvart, J.; Šácha, P.; Konvalinka. J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM´" The Prostate 2009, 69, 471-479.
149. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
148. Konvalinka, J.; Illnerová, H.; Hobza, P.; Hořejší, V.; Holý, A.; Jungwirth, P.; Pačes, V.; Martásek, P.; Zlatuška, J.: "Czech bibliometric system fosters mediocre research" Nature 2009, 460, 1079.
147. Hlouchová, K.; Barinka, C.; Konvalinka, J,; Lubkowski, J.: "Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III" FEBS J. 2009, 276, 4448-4462.
146. Grantz Šašková, K.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Yashina, T.; Kagan, R.K.; Konvalinka, J.: "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir" J. Virol. 2009, 83, 8810-8818.
145. Heyda, J.; Pokorná, J.; Vrbka, L.; Vácha, R.; Jagoda-Cwiklik, B.; Konvalinka, J.; Jungwirth, P.; Vonrášek, J.: "Ion specific effects of sodium and potassium on the catalytic activity of HIV-1 protease" Phys. Chem. Chem. Phys. 2009, 11, 7599-7604.
144. Hoffman, H.E.; Jirásková, J.; Cígler, P.; Šanda, M.; Schraml, J.; Konvalinka, J.: "Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5´-phosphate Cofactor" J. Med. Chem. 2009, 52, 6032-6041.
143. Řezáčová, P.; Pokorná, J.; Brynda, J.; Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáč, J.; Grantz Šašková, K.; Sieglová, I.; Plešek, J.; Šícha, V.; Grüner, B.; Oberwinkler, H.; Sedláček, J.; Kräusslich, H.-G.; Hobza, P.; Král, V.; Kovalinka, J.: "Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes" J. Med. Chem. 2009, 52, 7132-7141.
142. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
141. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
140. Šála, M.; Hřebabecký, H; Dračínský, M; Masojídková, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Norbornane as the novel pseudoglycone moiety in nucleosides" Tetrahedron 2009, 65, 9291-9299.
139. Hřebabecký, H.; Dračínský, M.; Holý, A.: "New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2-dimethanol template" Collect. Czech. Chem. Commun. 2009, 74, 1425-1441.
138. Doláková, P.; Dračínský, M.; Masojídková, M.; Šolínová, V.; Kašička, V.; Holý, A.: "Acyclic Nucleoside Bisphosphonates: Synthesis and Properties of Chiral 2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines" Eur. J. Med. Chem. 2009, 44, 2408-2424.
137. Doláková, P.; Dračínský, M.; Fanfrlík, J.; Holý, A.: "Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing Phosphonomethylphosphinyl Moiety and Studies of Their Phosphorylation Reaction" Eur. J. Org. Chem. 2009, 7, 1082-1092.
136. Hocková, D.; Holý, A.; Masojídková, M.; Keough, D. T.; de Jersey, J.; Guddat, L. W.: "Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit /Plasmodium falciparum/ hypoxanthine-guanine-xanthine phosphoribosyltransferase" Bioorg. Med. Chem. 2009, 17, 6218-6232.
135. Keough, D. T.; Hocková, D.; Holý, A.; Naesens, L.; Skinner- Adamsm, T.; de Jersey, J.; Guddat, L. W.: "Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics" J. Med. Chem. 2009, 52, 4391-4399.
134. Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.: "Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase" Tetrahedron 2009, 65, 8486-8492.
133. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of (Purin-6-yl)acetates and Their Transformations to 6-(2-Hydroxyethyl)- and 6-(Carbamoylmethyl)purines" Collect. Czech. Chem. Commun 2009, 74, 1035-3059.
132. Otová, B.; Hrdý, J.; Votruba, I.; Holý, A.: "In Vivo Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG" Anticancer Res. 2009, 29, 1295-1302.
131. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
130. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
129. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel Racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
128. Mlčochová, P.; Bařinka, C.; Tykvart, J.; Šácha, P.; Konvalinka, J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM'" Prostate 2009, 69, 471-479.
127. Zábranský, A.; Hadravová, R.; Štokrová, J.; Sakalian, M.; Pichová, I.: "Premature processing of mouse mammary tumor virus Gag polyprotein impairs intracellular capsid assembly" Virology 2009, 384, 33-37.
126. Kohoutová, Z.; Rumlová, M.; Andreánsky, M.; Sakalian, M.; Hunter, E.; Pichová, I.; Ruml, T.: "The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus" Virology 2009, 384, 59-68.
125. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoro­borates; The Scope and Limitations in the Synthesis of Modified Purines" Synthesis 2009, 1309-1317.
124. Novotný, M.; Hrabálek, A.; Janůšková, B.; Novotný, J.; Vávrová, K.: "Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers" Bioorg. Med. Chem. Lett. 2009, 19, 344-347.
123. Novotný, J.; Janůšková, B.; Novotný, M.; Hrabálek, A.; Vávrová, K.: "Short-Chain Ceramides Decrease Skin Barrier Properties" Skin. Pharmacol. Physiol. 2009, 22, 22-30.
122. Hoffman, H. E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2009, 63, 62-67.