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Centre for New Antivirals and Antineoplastics
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 Centre for New Antivirals and Antineoplastics
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212. Dejmek, M.; Hřebabecký, H.; Dračínský, M.; Neyts, J.; Leyssen, P.; Mertlíková-Kaiserová, H.; Nencka, R.: "Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxanorbornane and their antiviral properties" Collect. Czech. Chem. Commun. 2011, 76, 1549-1566.
211. Dejmek, M.; Hřebabecký, H.; Šála, M.; Dračínský, M.; Nencka, R.: "Microwave-Assisted Solvent-Free Diels-Alder Reaction - A Fast and Simple Route to Various 5,6-Substituted Norbornenes and Polychlorinated Norbornenes" Synthesis 2011, 24, 4077-4083.
210. Šála, M.; De Palma, A. M.; Hřebabecký, H.; Dejmek, M.; Dračínský, M.; Leyssen, P.; Neyts, J.; Mertlíková-Kaiserová, H.; Nencka, R.: "SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors" Bioorg. Med. Chem. Lett. 2011, 21, 4271-4275.
209. Mertlíková-Kaiserová, H.; Rumlová, M.; Tloušťová, E.; Procházková, E.; Holý, A.; Votruba, I.: "Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG" Biochem. Pharmacol. 2011, 82, 131-138.
208. Matoušová, M.; Votruba, I.; Otmar, M.; Tloušťová, E.; Günterová, J.; Mertlíková-Kaiserová, H.: "2´-Deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential" Epigenetics 2011, 6, 769-776.
207. Jansa, P.; Baszczyňski, O.; Dračínský, M.; Votruba, I.; Zídek, Z.; Bahador, G.; Stepan, G.; Cihlar, T.; Mackman, R.; Holý, A.; Janeba, Z.: "A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities" Eur. J. Med. Chem. 2011, 46, 3748-3754.
206. Břehová, P.; Česnek, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction" Tetrahedron 2011, 67, 7379-7385.
205. Jansa, P.; Špaček, P.; Votruba, I.; Břehová, P.; Dračínský, M.; Klepetářová, B.; Janeba, Z.: "Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol" Collect. Czech. Chem. Commun. 2011, 76, 1121-1131.
204. Jersey, J.; Holý, A.; Hocková, D.; Naesens, L.; Keough, D. T.; Guddat, L. W.: "6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs" Curr. Top. Med. Chem. 2011, 11, 2085-2102.
203. Hocková, D.; Holý, A.; Andrei, G.; Snoeck, R.; Balzarini, J.: "Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity" Bioorg. Med. Chem. 2011, 19, 4445-4453.
202. Jansa, P.; Holý, A.; Dračínský, M.; Baszczyňski, O.; Česnek, M.; Janeba, Z.: "Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction" Green Chem. 2011, 13, 882-888.
201. Sedláček, O.; Břehová, P.; Pohl, R.; Holý, A.; Janeba, Z.: "The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions" Can. J. Chem. 2011, 89, 488-498.
200. Baszczyňski, O.; Jansa, P.; Dračínský, M.; Klepetářová, B.; Holý, A.; Votruba, I.; De Clercq, E.; Balzarini, J.; Janeba, Z.: "Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines" Bioorg. Med. Chem. 2011, 19, 2114-2124.
199. Dračínský, M.; Jansa, P.; Ahonen, K.; Buděšínský, M.: "Tautomerism and the Protonation/Deprotonation of Isocytosine in Liquid- and Solid-States Studied by NMR Spectroscopy and Theoretical Calculations" Eur. J. Org. Chem. 2011, 8, 1544-1551.
198. Dračínský, M.; Jansa, P.; Chocholoušová, J.; Vacek, J.; Kovačková, S.; Holý, A.: "Mechanism of the isotopic exchange reaction of the 5-H hydrogen of uracil derivatives in water and nonprotic solvents" Eur. J. Org. Chem. 2011, 4, 777-785.
197. Čechová, L.; Jansa, P.; Šála, M.; Dračínský, M.; Holý, A.; Janeba, Z.: "The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines" Tetrahedron 2011, 67, 866-871.
196. Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: "Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498–5507.
195. Nauš, P.; Perlíková, P.; Pohl, R.; Hocek, M.: "Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2'-C-methylribonucleosides, arabinonucleosides and 2'-deoxy-2'-fluoroarabinonucleosides" Collect. Czech. Chem. Commun. 2011, 76, 957-988.
194. Tichý, T.; Andrei, G.; Dračínský, M.; Holý, A.; Balzarini, J.; Snoeck, R.; Krečmerová, M.: "New prodrugs of Adefovir and Cidofovir" Bioorg. Med. Chem. 2011, 19, 3527-3539.
193. Topalis, D.; Lebeau, I.; Krečmerová, M.; Andrei, G.; Snoeck, R.: "Activity of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells" Antimicrob. Agents Chemother. 2011, 55, 1961-1967.
192. Otmar, M; Dračínský, M.; Krečmerová, M.; Balzarini, J.; Andrei, G; Snoeck, R.: "Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine" Heterocycles 2011, 84, 797-813.
191. Mařák, D.; Otmar, M.; Votruba, I.; Dračínský, M.; Krečmerová, M.: "8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2011, 21, 652-654.
190. Perlíková, P.; P.; Pohl, R.; Votruba, I.; Shih, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides" Bioorg. Med. Chem. 2011, 19, 229-242.
189. Krečmerová, M.; Holý, A.; Andrei, G.; Pomeisl, K.; Tichý, T.; Břehová, P.; Masojídková, M.; Dračínský, M.; Pohl, R.; Laflamme, G.; Naesens, L.; Hui, H.; Cihlar, T.; Neyts, J.; De Clercq, E.; Balzarini, J.; Snoeck, R.: "Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents" J. Med. Chem. 2010, 53, 6825-6837.
188. Elbert, T.; Břehová, P.; Holý, A.: "The preparation of 3H-labeled acyclic nucleoside phosphonates and study of their stability" Collect. Czech. Chem. Commun. 2010, 75, 757-766.
187. Janeba, Z.; Holý, A.; Pohl, R.; Snoeck, R.; Andrei, G.; De Clercq, E.; Balzarini, J.: "Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base" Can. J. Chem. 2010, 88, 628-638.
186. Hocková, D.; Dračínský, M.; Holý, A.: "Synthesis and properties of a novel type of acyclic nucleoside phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic acids" Eur. J. Org. Chem. 2010, 2885-2892.
185. Hoffman, H.E.; Jiraskova, J.; Zvelebil, M.; Konvalinka, J.: "Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity" Collect. Czech. Chem. Commun. 2010, 5, 59-79.
184. Fanfrlik, J.; Bronowska, A.K.; Rezac, J.; Prenosil, O.; Konvalinka, J.; Hobza, P.: "A Reliable Docking/Scoring Scheme Based on the Semiempirical Quantum Mechanical PM6-DH2 Method Accurately Covering Dispersion and H-Bonding: HIV-1 Protease with 22 Ligands" J. Phys. Chem. B. 2010, 114, 12666-12678.
183. Zabransky, A.; Hoboth, P.; Hadravová, R.; Stokrova, J.; Sakalian, M.; Pichová, I.: "The noncanonical Gag domains p8 and n are critical for assembly and release of mouse mammary tumor virus" J. Virol. 2010, 84, 11555-11559.
182. Bohmová, K.; Hadravová, R.; Stokrova, J.; Tuma, R.; Ruml, T.; Pichová, I.; Rumlová, M.: "The effect of dimerizing domains and basic residues on in vitro and in vivo assembly of Mason-Pfizer monkey virus and Human immunodeficiency virus" J. Virol. 2010, 84, 1977-1988.
181. Krečmerová, M.; Holý, A.; Andrei, G.; Pomeisl, K.; Tichý, T.; Břehová, P.; Masojídková, M.; Dračínský, M.; Pohl, R.; Laflamme, G.; Naesens, L.; Hui, H.; Cihlar, T.; Neyts, J.; De Clercq, E.; Balzarini, J.; Snoeck, R.: "Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents" J. Med. Chem. 2010, 53, 6825-6837.
180. Huerfano, S.; Žíla, V.; Bouřa, E.; Španielová, H.; Štokrová, J.; Forstová, J.: "Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection" FEBS Journal 2010, 277, 1270-1283.
179. Betík, R.; Herrmann, P.; Kotora, M.: "Synthesis of an (±)-Estrone Precursor: the Scope of Zr- and Co-mediated Cycloannulations" Eur. J. Org. Chem. 2010, 646-655.
178. Novotný, J.; Hrabálek, A.; Vávrová, K.: "Synthesis and Structure-Activity Relationships of Skin Ceramides" Curr. Med. Chem. 2010, 17, 2301-2324.
177. Novotný, M.; Hrabálek, A.; Janůšová, B.; Novotný, J.; Vávrová, K.: "Transkarbams as transdermal permeation enhancers: Effects of ester position and ammonium carbamate formation" Bioorg. Med. Chem. Lett. 2010, 20, 2726-2728.
176. Myles, L.; Gore, R.; Špulák, M.; Gathergood, N.; Connon, S. J.: "Highly recyclable, imidazolium derived ionic liquids of low antimicrobial and antifungal toxicity: A new strategy for acid catalysis" Green Chem. 2010, 12, 1157-1162.
175. Schiller, R.; Tichotová, L.; Pavlík, J.; Buchta, V.; Melichar, B.; Votruba, I.; Kuneš, J.; Špulák, M.; Pour, M.: "3,5-Disubstituted pyranone analogues of highly antifungally active furanones: Conversion of biological effect from antifungal to cytostatic" Bioorg. Med. Chem. Lett. 2010, 20, 7358-7360.
174. Nencka, R.; Hřebabecký, H.; Dračínský, M.: "Model synthesis of six-membered carbocyclic spironucleosides" Collect. Czech. Chem. Commun. 2010, 75, 1259-1272.
173. Nencka, R.; Šála, M.; Dejmek, M.; Dračínský, M.; Holý, A.; Hřebabecký, H.: "Two convergent approaches toward novel carbocyclic C-nucleosides" Synthesis 2010, 4119-4130.
172. Šála, M.; De Palma, A. M.; Hřebabecký, H.; Nencka, R.; Dračínský, M.; Leyssen, P.; Neyts, J.; Holý, A.: "Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors" Bioorg. Med. Chem. 2010, 18, 4374-4384.
171. Šála, M.; Hřebabecký, H.; Dračínský, M.; Masojídková, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene" Collect. Czech. Chem. Commun. 2010, 75, 1-20.
170. Votruba, I.; Trýznová, J.; Břehová, P.; Tloušťová, E.; Horská, K.; Fanfrlík, J.; Přenosil, O.; Holý, A.: "Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners" Collect. Czech. Chem. Commun. 2010, 75, 1249-1257.
169. Opekar, S.; Turek, P.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.; Kotora, M.: "[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with α,ω-Diynes" Heterocycles 2010, 82, 895-907.
168. Šenel, P.; Tichotová, L.; Votruba, I.; Buchta, V.; Špulák, M.; Kuneš, J.; Nobilis, M.; Krenk, O.; Pour, M.: "Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives" Bioorg. Med. Chem. 2010, 18, 1988-2000.
167. Hájek, M.; Cvilink, V.; Votruba, I.; Holý, A.; Mertlíková-Kaiserová, H.: "Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP" Eur. J. Pharmacol. 2010, 643, 6-12.
166. Mertlíková-Kaiserová, H.; Votruba, I.; Matoušová, M.; Holý, A.; Hájek, M.: "Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM Cells" Anticancer Res. 2010, 30, 2791-2798.
165. Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases" ChemMedChem 2010, 5, 1386-1396.
164. Krečmerová, M.; Masojídková, M.; Holý, A.: "Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position" Bioorg. Med. Chem. 2010, 18, 387-395.
163. Keough, D.T.; Hocková, D.; Krečmerová, M.; Česnek, M.; Holý, A.; Naesens, L.; Brereton, I.M.; Winzor, D.J.; de Jersey, J.; Guddat, L.W.: "Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy" Mol. Biochem. Parasitol. 2010, 173, 165-169.
162. Hasník, Z.; Pohl, R.; Hocek, M.: "Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides" Tetrahedron Lett. 2010, 51, 2464-2466.
161. Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkus, G.; Wang, T.; Ray, A.S.; Mackman, R.; Cihlar, T.; Hocek, M.: "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460–470.
160. Bobula, T.; Hocek, M.; Kotora, M.: "Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides" Tetrahedron 2010, 66, 530-536.
159. Hrusková, V.; Morávková, A.; Babiarová, K.; Ludvíková, V.; Fricl, J.; Vonka, V.; Forstová, J.: "Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles" Int. J. Oncol. 2009, 35, 1247-1256.
158. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "Mapping of HIV-1 integrase preferences for target site selection with various oligonucleotides" Arch. Biochem. Biophys. 2009, 488, 153-162.
157. Macek, P.; Chmelík, J.; Křížová, I.; Kadeřávek, P.; Padrtal, P.; Žídek, L.; Wildová, M.; Hadravová, R.; Chaloupková, R.; Pichová, I.; Ruml, T.; Rumlová, M.; Sklenář, V.: "NMR Structure of the N-Terminal Domain of Capsid Protein from the Mason–Pfizer Monkey Virus" J. Mol. Biol. 2009, 392, 100-114.
156. Kohoutová, Z.; Rumlová, M.; Andreánsky, M.; Sakalian, M.; Hunter, E.; Pichová, I.; Ruml, T.: "The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus" Virology 2009, 384, 59-68.
155. Zábranský, A.; Hadravová, R.; Štokrová, J.; Sakalian, M.; Pichová, I.: "Premature processing of mouse mammary tumor virus Gag polyprotein impairs intracellular capsid assembly" Virology 2009, 384, 33-37.
154. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "The strand transfer oligonucleotide inhibitors of HIV-integrase" J. Enzym. Inhib. Med. Ch. 2009, 24, 241-246.
153. Zídek, Z.; Anzenbacher, P.; Kmoníčková, E.: "Current status and challenges of cytokine pharmacology" Brit. J. Pharmacol. 2009, 157, 342-361.
152. Vaněk, V.; Buděšínský, M.; Kabeleová, P.; Šanda, M.; Kožíšek, M.; Hančlová, I.; Mládková, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiráček, J.: "Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase" J. Med. Chem. 2009, 52, 3652-3665.
151. Pokorna, J.; Machala, L.; Rezacova, P.; Konvalinka, J.: "Current and Novel Inhibitors of HIV Protease" Viruses 2009, 1, 1209-1239.
150. Mlčochová, P.; Bařinka, P.; Tykvart, J.; Šácha, P.; Konvalinka. J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM´" The Prostate 2009, 69, 471-479.
149. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
148. Konvalinka, J.; Illnerová, H.; Hobza, P.; Hořejší, V.; Holý, A.; Jungwirth, P.; Pačes, V.; Martásek, P.; Zlatuška, J.: "Czech bibliometric system fosters mediocre research" Nature 2009, 460, 1079.
147. Hlouchová, K.; Barinka, C.; Konvalinka, J,; Lubkowski, J.: "Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III" FEBS J. 2009, 276, 4448-4462.
146. Grantz Šašková, K.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Yashina, T.; Kagan, R.K.; Konvalinka, J.: "Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir" J. Virol. 2009, 83, 8810-8818.
145. Heyda, J.; Pokorná, J.; Vrbka, L.; Vácha, R.; Jagoda-Cwiklik, B.; Konvalinka, J.; Jungwirth, P.; Vonrášek, J.: "Ion specific effects of sodium and potassium on the catalytic activity of HIV-1 protease" Phys. Chem. Chem. Phys. 2009, 11, 7599-7604.
144. Hoffman, H.E.; Jirásková, J.; Cígler, P.; Šanda, M.; Schraml, J.; Konvalinka, J.: "Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5´-phosphate Cofactor" J. Med. Chem. 2009, 52, 6032-6041.
143. Řezáčová, P.; Pokorná, J.; Brynda, J.; Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáč, J.; Grantz Šašková, K.; Sieglová, I.; Plešek, J.; Šícha, V.; Grüner, B.; Oberwinkler, H.; Sedláček, J.; Kräusslich, H.-G.; Hobza, P.; Král, V.; Kovalinka, J.: "Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes" J. Med. Chem. 2009, 52, 7132-7141.
142. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
141. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
140. Šála, M.; Hřebabecký, H; Dračínský, M; Masojídková, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Norbornane as the novel pseudoglycone moiety in nucleosides" Tetrahedron 2009, 65, 9291-9299.
139. Hřebabecký, H.; Dračínský, M.; Holý, A.: "New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2-dimethanol template" Collect. Czech. Chem. Commun. 2009, 74, 1425-1441.
138. Doláková, P.; Dračínský, M.; Masojídková, M.; Šolínová, V.; Kašička, V.; Holý, A.: "Acyclic Nucleoside Bisphosphonates: Synthesis and Properties of Chiral 2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines" Eur. J. Med. Chem. 2009, 44, 2408-2424.
137. Doláková, P.; Dračínský, M.; Fanfrlík, J.; Holý, A.: "Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing Phosphonomethylphosphinyl Moiety and Studies of Their Phosphorylation Reaction" Eur. J. Org. Chem. 2009, 7, 1082-1092.
136. Hocková, D.; Holý, A.; Masojídková, M.; Keough, D. T.; de Jersey, J.; Guddat, L. W.: "Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit /Plasmodium falciparum/ hypoxanthine-guanine-xanthine phosphoribosyltransferase" Bioorg. Med. Chem. 2009, 17, 6218-6232.
135. Keough, D. T.; Hocková, D.; Holý, A.; Naesens, L.; Skinner- Adamsm, T.; de Jersey, J.; Guddat, L. W.: "Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics" J. Med. Chem. 2009, 52, 4391-4399.
134. Pomeisl, K.; Holý, A.; Pohl, R.; Horská, K.: "Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase" Tetrahedron 2009, 65, 8486-8492.
133. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of (Purin-6-yl)acetates and Their Transformations to 6-(2-Hydroxyethyl)- and 6-(Carbamoylmethyl)purines" Collect. Czech. Chem. Commun 2009, 74, 1035-3059.
132. Otová, B.; Hrdý, J.; Votruba, I.; Holý, A.: "In Vivo Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG" Anticancer Res. 2009, 29, 1295-1302.
131. Klusák, V.; Bařinka, C.; Plechanovová, A.; Mlčochová, P.; Konvalinka, J.; Rulíšek, L.; Lubkowski, J.: "Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods" Biochemistry 2009, 48, 4126-4138.
130. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol" Collect. Czech. Chem. Commun. 2009, 74, 487-502.
129. Hřebabecký, H.; Dračínský, M.; De Palma, A. M.; Neyts, J.; Holý, A.: "Synthesis of novel Racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses" Collect. Czech. Chem. Commun. 2009, 74, 469-485.
128. Mlčochová, P.; Bařinka, C.; Tykvart, J.; Šácha, P.; Konvalinka, J.: "Prostate-Specific Membrane Antigen and Its Truncated Form PSM'" Prostate 2009, 69, 471-479.
127. Zábranský, A.; Hadravová, R.; Štokrová, J.; Sakalian, M.; Pichová, I.: "Premature processing of mouse mammary tumor virus Gag polyprotein impairs intracellular capsid assembly" Virology 2009, 384, 33-37.
126. Kohoutová, Z.; Rumlová, M.; Andreánsky, M.; Sakalian, M.; Hunter, E.; Pichová, I.; Ruml, T.: "The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus" Virology 2009, 384, 59-68.
125. Hasník, Z.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Cross-Coupling Reactions of Halopurines with Aryl- and Alkyltrifluoro­borates; The Scope and Limitations in the Synthesis of Modified Purines" Synthesis 2009, 1309-1317.
124. Novotný, M.; Hrabálek, A.; Janůšková, B.; Novotný, J.; Vávrová, K.: "Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers" Bioorg. Med. Chem. Lett. 2009, 19, 344-347.
123. Novotný, J.; Janůšková, B.; Novotný, M.; Hrabálek, A.; Vávrová, K.: "Short-Chain Ceramides Decrease Skin Barrier Properties" Skin. Pharmacol. Physiol. 2009, 22, 22-30.
122. Hoffman, H. E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2009, 63, 62-67.
121. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "The strand transfer oligonucleotide inhibitors of HIV-integrase" J. Enzym. Inhib. Med. Chem. 2008, 24, 241-246.
120. Klimentová, J.; Kosák, P.; Vávrová, K.; Holas, T.; Novotný, J.; Hrabálek, A.: "Transkarbams with Terminal Branching as Transdermal Permeation Enhancers" Bioorg. Med. Chem. Lett. 2008, 18, 1712-1715.
119. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers" Eur. J. Pharm. Biopharm. 2008, 70, 597-604.
118. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species" Eur. J. Pharm. Biopharm. 2008, 70, 901-907.
117. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and Homocyclotrimerization Reactions of Protected 1-Alkynyl-2-deoxyribofuranose. Synthesis of C-Nucleosides, C-Di- and C-Trisaccharide Analogues" Tetrahedron 2008, 64, 5200-5207.
116. Janková, Š.; Dračínský, M.; Císařová, I.; Kotora, M.: "Synthesis and Rearrangement of Dewar Benzenes into Biaryls. Experimental Evidence for the Conrotatory Ring Opening" Eur. J. Org. Chem. 2008, 47-51.
115. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave Enhanced [2+2+2]-Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
114. Eignerová, B.; Dračínský, M.; Kotora, M.: "Perfluoroalkylation via Cross-metathesis of Alkenes with (Perfluoroalkyl)propenes" Eur. J. Org. Chem. 2008, 4493-4499.
113. Herrmann, P.; Buděšínský, M.; Kotora, M.: "Total Synthesis of (±)-Estrone and Zirconocene-Promoted Cyclization of 2-Fluoro-1,7-octadienes and Ru-Catalyzed Ring Closing metathesis" J. Org. Chem. 2008, 73, 6202-6206.
112. Novák, P.; Pour, M.; Špulák, M.; Votruba, I.; Kotora, M.: "Extention of the Library of Biological Active γ-Alkylidene Butenolides" Synthesis 2008, 3465-3472.
111. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol" Collect. Czech. Chem. Commun. 2008, 73, 44-58.
110. Bartoňová, V.; Král, V.; Sieglová, I.; Brynda, J.; Fábry, M.; Hořejší, M.; Kožíšek, M.; Grantz Šašková, K.; Konvalinka, J.; Sedláček, J.; Řezáčová, P.: "Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies" Antiviral Res. 2008, 78, 275-277.
109. Řezáčová, P.; Kožíšek, M.; Moy, S.F.; Sieglová, I.; Joachimiak, A.; Machius, M.; Otwinowski, Z.: "Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates" Mol Microbiol. 2008, 69, 895-910.
108. Kožíšek, M.; Svatoš, A.; Budešínský, M.; Muck, A.; Bauer, M.C.; Kotrba, P.; Ruml, T.; Havlas, Z.; Linse, S.; Rulíšek, L.: "Molecular design of specific metal-binding peptide sequences from protein fragments" Chemistry-Eur. J. 2008, 14, 7836-7846.
107. Cígler, P.; Král, V.; Kožíšek, M.; Konvalinka, J.; Mirsky, V.: "Anomalous adsorptive properties of HIV protease: Indication of two-dimensional crystallization?" Colloids and Surfaces B: Biointerfaces 2008, 64, 145-149.
106. Král, V.; Mader, P.; Collard, R.; Fábry, M.; Hořejší, M.; Řezáčová, P.; Kožíšek, M.; Závada, J.; Sedláček, J.; Rulíšek, M.; Brynda, J.: "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations" Proteins 2008, 71, 1275-1287.
105. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2008, 63, 62-67.
104. Grantz Šašková, K.; Kožíšek, M.; Lepšík, M.; Brynda, J.; Řezáčová, P.; Václavíková, J.; Kagan, R.; Machala, L.; Konvalinka, J.: "Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility to HIV Protease Inhibitor Lopinavir" Protein Sci. 2008, 17, 1555-1564.
103. Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáčová, P.; Brynda, J.; Pokorná, J.; Plešek, J.; Gruner, B.; Grantz Šašková, K.; Václavíková, J.; Král, V.; Konvalinka, J.: "Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming, Antiviral Resistance" J. Med. Chem. 2008, 51, 4839-4843.
102. Kožíšek, M.; Grantz Šašková, K.; Řezáčová, P.; Maarseveen, N.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.N.; Konvalinka, J.: "Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region" J. Virol. 2008, 82, 5869-5878.
101. Wildová, M.; Hadravová, R.; Štokrová, J.; Křížová, I.; Ruml, T.; Hunter, E.; Pichová, I.; Rumlová, M.: "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" Virology 2008, 380, 157-163.
100. Macek, P.; Žídek, L.; Rumlová, M.; Pichová, I.; Sklenář, V.: "1H, 13C, and 15N resonance assignment of the N-terminal domain of Mason-Pfizer monkey virus capsid protein, CA 1-140" Biomol NMR Assign 2008, 2, 43-45.
99. Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, H.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.: "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" J. Virol. 2008, 82, 12520-12534.
98. Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic polymerization of phosphonate nucleosides" ChemBioChem 2008, 9, 2883-2888.
97. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
96. Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.: "Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine" Biochem. Pharmacol. 2008, 76, 997-1005.
95. Votruba, I.; Otová, B.; Holý, A.: "Acyklické nukleosidfosfonáty jako potenciální antineoplastika" Čas. Lék. čes. 2008, 147, 471-477.
94. Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines" Tetrahedron 2008, 64, 10355-10364.
93. Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665-678.
92. Dračínský, M.; Krečmerová, M.; Holý, A.: "Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy" Bioorg. Med. Chem. 2008, 16, 6778-6782.
91. Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations" Org. Biomol. Chem. 2008, 6, 2377-2387.
90. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
89. Bambuch, V.; Pohl, R.; Hocek, M.: "Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides" Eur. J. Org. Chem. 2008, 2783-2788.
88. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues" Tetrahedron 2008, 64, 5200-5207.
87. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
86. Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlar, T.; Holý, A.: "Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates" Collect. Czech. Chem. Commun. 2008, 73, 275-291.
85. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide – Scope and Limitations of the Reaction" Synlett 2008, 543–546.
84. Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.: "Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells" Biochem. Pharmacol. 2008, 75, 965-972.
83. Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.: "Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2008, 18, 1364-1367.
82. Rovenská, M.; Hlouchová, K.; Šácha, P.; Mlčochová, P.; Horák, V.; Zámečník, J.; Bařinka, C.; Konvalinka, J.: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs" Prostate 2008, 68, 171-182.
81. Bařinka, C.; Hlouchová, K.; Rovenská, M.; Majer, P.; Dauter, M.; Hin, N.; Ko, Y.-S.; Tsukamoto, T.; Slusher, B.S., Konvalinka, J.; Lubkowski, J.: "Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs" J. Mol. Biol. 2008, 376, 1438-1450.
80. Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides" Bioorg. Med. Chem. 2008, 16, 1400–1424.
79. Pomeisl, K.; Votruba, I.; Holý, A.; Pohl, R.: "Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-lymphoma" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1025-1028.
78. Dejmek, M.; Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 2-(hydroxymethyl)bicyclo[2.2.1]heptane" Collect. Czech. Chem. Commun. 2007, 72, 1523-1544.
77. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleosides and Pro-Tides derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol" Collect. Czech. Chem. Commun. 2007, 72, 1331-1349.
76. Zápotocký, M.; Hanzalová, J.; Starková, J.; Votruba, I.; Holý, A.; Otová, B.: "Experimental Therapy with 9-[2-(Phosphonomethoxy)ethyl]- 2,6-diaminopurine (PMEDAP): Origin of Resistance" Folia Biologica (Praha) 2007, 53, 79-84.
75. Nencka, R.; Votruba, I.; Hřebabecký, H.; Jansa, P.; Tloušťová, E.; Horská, K.; Masojídková, H.; Holý, A.: "Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase" J. Med. Chem. 2007, 50, 6016-6023.
74. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines" Collect. Czech. Chem. Commun. 2007, 72, 965-983.
73. Potměšil, P; Holý, A.; Kmoníčková, E.; Křížková, J.; Zídek, Z.: "Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3" J. Biomed. Sci. 2007, 14, 59-66.
72. Duraffour, S.; Snoeck, R.; Krečmerová, M.; van Den Oord, K.; De Vos, R.; Holý, A.; Crance, J.-M.; Garin, D.; De Clercq. E.; Andrei, G.: "Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models" Antimicrob. Agents Chemother. 2007, 51, 4410-4419.
71. Krečmerová, M.; Holý, A.; Pohl, R.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" J. Med. Chem. 2007, 50, 5765-5772.
70. Kožíšek, M.; Bray, J.; Řezáčová, P.; Šašková, K.; Brynda, J.; Pokorná, J.; Mammano, F.; Rulíšek, L.; Konvalinka, J.: "Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants" J. Mol. Biol. 2007, 374, 1005-1016.
69. Bambuch, V.; Otmar, M.; Pohl, R.; Masojídková, M.; Holý, A.: "C-Functionalization of 9-deazapurines by cross-coupling reactions" Tetrahedron 2007, 63, 1589-1601.
68. Krečmerová, M.; Holý, A.; Pískala, A.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds" J. Med. Chem. 2007, 50, 1069-1077.
67. Renders, M.; Emmerechts, G.; Rozenski, J.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase" Angew. Chem. Int. Ed. 2007, 46, 2501-2504.
66. Lebeau, I.; Andrei, G.; Krečmerová, M.; De Clercq, E.; Holý, A.; Snoeck, R.: "Inhibitory activity of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate SV 40 strains" Antimicrob. Agents Chemother. 2007, 51, 2268-2273.
65. Krečmerová, M.; Holý, A.; Masojídková, M.: "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position" Collect. Czech. Chem. Commun. 2007, 72, 927-951.
64. Doláková, P.; Masojídková, M.; Holý, A.: "Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives" Heterocycles 2007, 71, 1107-1115.
63. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines" Tetrahedron: Asymmetry 2007, 18, 2233-2247.
62. Kmoníčková, E.; Melkusová, P.; Farghali, H.; Holý, A.; Zídek, Z.: "Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells" Nitric Oxide-Biol. Chem. 2007, 17, 160-169.
61. Zídek, Z.; Kmoníčková, E.; Holý, A.: "Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates" Eur. J. Pharmacol. 2007, 574, 77-84.
60. Vávrová, K.; Hrabálek, A.; Mac-Mary, S.; Humbert, P.; Muret, P.: "Ceramide analogue 14S24 selectively recovers perturbed human skin barrier" Brit. J. Dermatol. 2007, 157, 704-712.
59. Mlčochová, P.; Plechanovová, A.; Bařinka, C.; Mahadeva, D.; Saldanha, C.; Rulíšek, L.; Konvalinka, J.: "Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis" FEBS J 2007, 274, 4731-4741.
58. Bařinka, C.; Rovenská, M.; Mlčochová, P.; Hlouchová, K.; Plechanovová, A.; Majer, P.; Tsukamoto, T.; Slusher, B. S.; Konvalinka, J.; Lubkowski, J.: "Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II" J. Med. Chem. 2007, 50, 3267-3273.
57. Hasník, Z.; Šilhár, P.; Hocek, M.: "Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent" Tetrahedron Lett. 2007, 48, 5589-5592.
56. Vávrová, K.; Lorencová, K.; Klimentová, J.; Novotný, J.; Hrabálek, A.: "HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA)" J Chromatogr. B 2007, 853, 198-203.
55. Nobilis, M.; Pour, M.; Šenel, P.; Pavlík, J.; Kuneš, J; Vopršalová, M.; Kolářová, L.; Holčapek, M.: "Metabolic profiling of a potential antifungal drug, 3-(4-bromophenyl)-5-acetoxymethyl-2,5-dihydrofuran-2-one, in mouse urine using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection" J. Chromatogr. B 2007, 853, 10-19.
54. Kubát, P.; Lang, K.; Cígler, P.; Kožíšek, M.; Matějíček, M; Janda, P.; Zelinger, Z.; Procházka, K.; Král, V.: "Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease" J. Phys. Chem. B 2007, 111, 4539-4546.
53. Pomeisl, K.; Holý, A.; Pohl, R.: "Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potencial multisubstrate inhibitors of thymidine phosphorylase" Tetrahedron Lett. 2007, 48, 3065-3067.
52. Hlouchová, K.; Bařinka, C.; Klusák, V.; Šácha, P.; Mlčochová, P.; Majer, P.; Rulíšek, L.; Konvalinka, J.: "Biochemical characterization of human glutamate carboxypeptidase III" J. Neurochem. 2007, 101, 682-696.
51. Németh-Pongrácz, V.; Barabás, O.; Fuxreiter, M.; Simon, I.; Pichová, I.; Rumlová, M.; Zábranská, H.; Svergun, D.; Petoukhov, M; Harmat, V.; Klement, É; Hunyadi-Gulyás, É; Medzihradszky, K. F.; Kónya, E.; Vértessy, B. G.: "Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins" Nucl. Acids Res. 2007, 35, 495-505.
50. Zábranská, H.; Tůma, R.; Kluh, I.; Svatoš, A.; Ruml, T.; Hrabal, R.; Pichová, I.: "The Role of the S-S Bridge in Retroviral Protease Function and Virion Maturation" J. Mol. Biol. 2007, 365, 1493-1504.
49. Bařinka, C.; Starková, J.; Konvalinka, J.; Lubkowski, J.: "A high-resolution structure of ligand-free human glutamate carboxypeptidase II" Acta Cryst. 2007, F63, 150-153.
48. Šácha, P.; Zámečník, J.; Bařinka, C.; Hlouchová, K.; Vícha, A.; Mlčochová, P.; Hilgert, I.; Eckschlager, T.; Konvalinka, J.: "Expression of glutamate carboxypeptidase II in human brain" Neuroscience 2007, 144, 1361-1372.
47. Nijhuis, M.; van Maarseveen, N. M.; Lastere, S.; Schipper, P.; Coakley, E.; Glass, B.; Rovenska, M.; de Jong, D.; Chappey, C.; Goedegebuure, I. W.; Heilek-Snyder, G.; Dulude, D.; Cammack, N.; Brakier-Gingras, L.; Konvalinka, J.; Parkin, N.; Kräusslich, H. G.; Brun-Vezinet, F.; Boucher, C. A. B.: "A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism" PLoS Med 2007, 4, e36.
46. Németh-Pongrácz, V.; Snášel, J.; Rumlová, M.; Pichová, I.; Vértessy, B. G.: "Interacting partners of M-PMV nucleocapsid-dUTPase" Nucleos. Nucleot. Nucl. 2006, 25, 1197-1200.
45. Sobociková, M.; Štěpnička, P.; Ramella, D.; Kotora, M.: "Synthesis of 1-alkanoyl-1'-(trifluoroacetyl)ferrocenes" Collect. Czech. Chem. Commun. 2006, 71, 190-196.
44. Nečas, D.; Turský, M.; Tišlerová, I.; Kotora, M.: "Nickel-catalyzed cyclization of α,ω-dienes: formation vs. cleavage of C–C bonds" New J. Chem. 2006, 30, 671-674.
43. Turský, M.; Nečas, D.; Drabina, P.; Sedlák, M.; Kotora, M.: "Rhodium-Catalyzed Deallylation of Allylmalonates and Related Compounds" Organometallics 2006, 25, 901-907.
42. Herrmann, P.; Kotora, M.; Buděšínský, M.; Šaman, D.; Císařová, I.: "Synthesis of (±)-3-Methoxyestra-1,3,5(10)-trienes by the Repetitive Use of Negishi Reagent" Org. Lett. 2006, 8, 1315-1318.
41. Holý, A.: "Antiviral acyclic nucleoside phosphonates structure activity studies" Antivirals Res. 2006, 71, 248-253.
40. Česnek, M.; Masojídková, M.; Holý, A.; Šolínová, V.; Koval, D; Kašička, V.: "Synthesis and properties of 2-guanidinopurines" Collect. Czech. Chem. Commun. 2006, 71, 1303-1319.
39. Potměšil, P.; Krečmerová, M.; Kmoníčková, E.; Holý, A.; Zídek, Z.: "Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives" Eur. J. Pharmacol. 2006, 540, 191-199.
38. Hořejší, K.; Andrei, G.; De Clerq, E.; Snoeck, R.; Pohl, R; Holý, A.: "Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity" Bioorg. Med. Chem. 2006, 14, 8057-8065.
37. Šolínová, V.; Kašička, V.; Koval, D.; Česnek, M.; Holý, A.: "Determination of acid–base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis" Electrophoresis 2006, 27, 1006-1019.
36. Hocek, M.; Šilhár, P.; Pohl, R.: "Cytostatic and activiral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3'-deoxyribonucletides" Collect. Czech. Chem. Commun. 2006, 71, 1484-1496.
35. Turek, P.; Novák, P.; Pohl, R.; Hocek, M.; Kotora, M.: "Preparation of Highly Substituted 6-Arylpurine Ribonucleosides by Ni-Catalyzed Cyclotrimerization. Scope of the Reaction" J. Org. Chem. 2006, 71, 8978-8981.
34. Klimentová, J.; Kosák, P.; Vávrová, K.; Holas, T.; Hrabálek, A.: "Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids" Bioorg. Med. Chem. 2006, 14(23), 7681-7687.
33. Holas, T.; Vávrová, K.; Šíma, M.; Klimentová, J.; Hrabálek, A.: "Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12" Bioorg. Med. Chem. 2006, 14(23), 7671-7680.
32. Kuchař, M.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of Purines Bearing Functionalized C-Substituents by the Conjugate Addition of Nucleophiles to 6-Vinylpurines and 6-Ethynylpurines" Eur. J. Org. Chem. 2006, 5083-5098.
31. Liebl, D.; Difato, F.; Horníková, L.; Mannová, P.; Štokrová, J.; Forstová, J: "Mouse Polyomavirus Enters Early Endosomes, Requires Their Acidic pH for Productive Infection, and Meets Transferrin Cargo in Rab11-Positive Endosomes" J. Virol. 2006, 80, 4610-4622.
30. Hřebabecký, H.; Masojídková, M.; Dračínský, M.; Holý, A.: "Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol" Collect. Czech. Chem. Commun. 2006, 71, 871-888.
29. Šála, M.; Hřebabecký, H.; Masojídková, M.; Holý, A.: "Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo{2.2.1]hept-5-ene-2,2-dimethanols" Collect. Czech. Chem. Commun. 2006, 71, 635-649.
28. Hocek, M.; Šilhár, P.; Shih, I.; Mabery, E.; Mackman, R.: "Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine L-ribonucleosides" Bioorg. Med. Chem. Lett. 2006, 16, 5290-5293.
27. Hrabálek, A.; Doležal, P.; Vávrová, K.; Zbytovská, J.; Holas, T.; Klimentová, J.; Novotný, J.: "Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin" Pharm. Res. 2006, 5, 912-919.
26. Čapek, P.; Pohl, R.; Hocek, M.: "Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines." Org. Biomol. Chem. 2006, 4, 2278-2284.
25. Šilhár, P.; Pohl, R.; Votruba, I.; Klepetářová, B.; Hocek, M.: "Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl- 2-(Hydroxymethyl)purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2006, 71, 788-803.
24. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis and Cytostatic Activity of Novel 6-(Difluoromethyl)purine Bases and Nucleosides" Synthesis 2006, 1848-1852.
23. Krečmerová, M.; Masojídková, M.; Holý, A.: "Preparation of C-5 Substituted Cidofovir Derivatives" Collect. Czech. Chem. Commun. 2006, 71, 579-594.
22. Vrbovská, S.; Holý, A.; Pohl, R.; Masojídková, M.: "Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines" Collect. Czech. Chem. Commun. 2006, 71, 543-566.
21. Novák, P.; Pohl, R.; Kotora, M.; Hocek, M.: "Synthesis of C-Aryldeoxyribosides by [2 + 2 + 2]-Cyclotrimerization Catalyzed by Rh, Ni, Co, and Ru Complexes" Org. Lett. 2006, 8, 2051-2054.
20. Majerová-Uhlíková, T.; Dantuma, N. P.; Lindsten, K.; Masucci, M. G.; Konvalinka, J.: "Non-infectious Fluorimetric Assay for Phenotyping of Drug-Resistant HIV Proteinase Mutants" J. Clin. Virol. 2006, 36, 50-59.
19. Vale-Silva, L. A.; Buchta, V.; Vokurková, D.; Pour, M.: "Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow citometry" Bioorg. Med. Chem. Lett. 2006, 16, 2492-2495.
18. Matějíček, P., Cígler, P., Procházka, K., and Král, V.: "Molecular Assembly of Metallacarboranes in Water: Light Scattering and Microscopy Study" Langmuir 2006, 22, 575-581.
17. Mesters, J. R.; Bařinka, C.; Li, W., Tsukamoto, T.; Majer, P.; Slusher, B.; Konvalinka, J.; Hilgenfeld, R.: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer" EMBO J. 2006, 25, 1375-1384.
16. Hořejší, K.; Pohl, R.; Holý, A.: "Tricyclic purine analogs derived from 2-amino-6-chloropurine and 2,6-diaminopurine and their methylated quarternary salts" Collect. Czech. Chem. Commun. 2006, 71, 77-90.
15. Bouřa, E.; Liebl, D.; Špíšek, R.; Frič, J.; Marek, M.; Štokrová, J.; Holáň, V.; Forstová, J.: "Polyomavirus EGFP-pseudocapsids: Analysis of model particles for introduction of proteins and peptides into mammalian cells" FEBS Letters 2005, 579, 6549–6558.
14. Chalupová, Š.; Holý, A.; Masojídková, M.: "Synthesis of some N4-substituted derivatives of 1-[2-(phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N4-substituted derivatives of Cidofovir" Collect. Czech. Chem. Commun. 2005, 70, 2066-2074.
13. Chalupová, Š.; Holý, A.; Masojídková, M.: "Synthesis of some N4-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir)" Collect. Czech. Chem. Commun. 2005, 70, 2053-2065.
12. Bauerová-Zábranská, H.; Stokrová, J.; Stříšovský, K.; Hunter, E.; Ruml, T.; Pichová, I.: "The RNA Binding G-patch Domain in Retroviral Protease Is Important for Infectivity and D-type Morphogenesis of Mason-Pfizer Monkey Virus" J. Biol. Chem. 2005, 280, 42106-42112.
11. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "Synthesis of 2-Substituted 6-(Hydroxymethyl)Purine Bases and Nucleosides" Collect. Czech. Chem. Commun. 2005, 70, 1669-1695.
10. Čapek, P.; Hocek, M.: "Efficient One-Step Synthesis of Optically Pure (Adenin-8-yl)phenylalanine Nucleosides" Synlett 2005, 3005-3007.
9. Cígler, P.; Kožíšek, M.; Řezáčová, P.; Brynda, J.; Otwinowski, Z.; Pokorná, J.; Plešek, J.; Grüner, B.; Dolečková-Marešová, L.; Máša, M.; Sedláček, J.; Bodem, J.; Kräusslich, H.-G.; Král, V.; Konvalinka, J.: "From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease" Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 15394-15399.
8. Horáková, D.; Rumlová, M.; Pichová, I.; Ruml, T.: "Luminometric method for screening retroviral protease inhibitors" Anal. Biochem. 2005, 345, 96-101.
7. Vávrová, K.; Zbytovská, J.; Hrabálek, A.: "Amphiphilic transdermal permeation enhancers: Structure-activity relationships" Curr. Med. Chem. 2005, 12, 2273-2291.
6. Fáková, H.; Pour, M.; Kuneš, J.; Šenel, P.: "Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine and its analogues" Tetrahedron Lett. 2005, 46, 8137-8140.
5. Hájek, M.; Matulová, N.; Votruba, I.; Holý, A.; Tloušťová, E.: "Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates" Biochem. Pharmacol. 2005, 70, 894-900.
4. Čapek, P.; Pohl, R.; Hocek, M.: "Synthesis of Enantiomerically Pure (Purin-6-yl)phenylalanines and Their Nucleosides, a Novel Type of Purine-Amino Acid Conjugates" J. Org. Chem. 2005, 70, 8001-8008.
3. Hocek, M.; Nauš, P.; Pohl, R.; Votruba, I.; Furman, P. A.; Tharnish, P. M.; Otto, M. J.: "Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides" J. Med. Chem. 2005, 48, 5869-5873.
2. Šilhár, P.; Pohl, R.; Votruba, I.; Hocek, M.: "The First Synthesis and Cytostatic Activity of Novel 6-(Fluoromethyl)purine Bases and Nucleosides" Org. Biomol. Chem. 2005, 3, 3001-3007.
1. Hocek, M.; Pohl, R.; Císařová, I.: "Highly Methylated Purines and Purinium Salts as Analogues of Heteromines" Eur. J. Org. Chem. 2005, 3026-3030.