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Centre for New Antivirals and Antineoplastics
Suported by the Ministry of Education, Czech Republic
 Centre for New Antivirals and Antineoplastics
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Publications List of Publications 2008

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121. Snášel, J.; Rosenberg, I.; Pačes, O.; Pichová, I.: "The strand transfer oligonucleotide inhibitors of HIV-integrase" J. Enzym. Inhib. Med. Chem. 2008, 24, 241-246.
120. Klimentová, J.; Kosák, P.; Vávrová, K.; Holas, T.; Novotný, J.; Hrabálek, A.: "Transkarbams with Terminal Branching as Transdermal Permeation Enhancers" Bioorg. Med. Chem. Lett. 2008, 18, 1712-1715.
119. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers" Eur. J. Pharm. Biopharm. 2008, 70, 597-604.
118. Vávrová, K.; Lorencová, K.; Novotný, J.; Holý, A.; Hrabálek, A.: "Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species" Eur. J. Pharm. Biopharm. 2008, 70, 901-907.
117. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and Homocyclotrimerization Reactions of Protected 1-Alkynyl-2-deoxyribofuranose. Synthesis of C-Nucleosides, C-Di- and C-Trisaccharide Analogues" Tetrahedron 2008, 64, 5200-5207.
116. Janková, Š.; Dračínský, M.; Císařová, I.; Kotora, M.: "Synthesis and Rearrangement of Dewar Benzenes into Biaryls. Experimental Evidence for the Conrotatory Ring Opening" Eur. J. Org. Chem. 2008, 47-51.
115. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave Enhanced [2+2+2]-Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
114. Eignerová, B.; Dračínský, M.; Kotora, M.: "Perfluoroalkylation via Cross-metathesis of Alkenes with (Perfluoroalkyl)propenes" Eur. J. Org. Chem. 2008, 4493-4499.
113. Herrmann, P.; Buděšínský, M.; Kotora, M.: "Total Synthesis of (±)-Estrone and Zirconocene-Promoted Cyclization of 2-Fluoro-1,7-octadienes and Ru-Catalyzed Ring Closing metathesis" J. Org. Chem. 2008, 73, 6202-6206.
112. Novák, P.; Pour, M.; Špulák, M.; Votruba, I.; Kotora, M.: "Extention of the Library of Biological Active γ-Alkylidene Butenolides" Synthesis 2008, 3465-3472.
111. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol" Collect. Czech. Chem. Commun. 2008, 73, 44-58.
110. Bartoňová, V.; Král, V.; Sieglová, I.; Brynda, J.; Fábry, M.; Hořejší, M.; Kožíšek, M.; Grantz Šašková, K.; Konvalinka, J.; Sedláček, J.; Řezáčová, P.: "Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies" Antiviral Res. 2008, 78, 275-277.
109. Řezáčová, P.; Kožíšek, M.; Moy, S.F.; Sieglová, I.; Joachimiak, A.; Machius, M.; Otwinowski, Z.: "Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates" Mol Microbiol. 2008, 69, 895-910.
108. Kožíšek, M.; Svatoš, A.; Budešínský, M.; Muck, A.; Bauer, M.C.; Kotrba, P.; Ruml, T.; Havlas, Z.; Linse, S.; Rulíšek, L.: "Molecular design of specific metal-binding peptide sequences from protein fragments" Chemistry-Eur. J. 2008, 14, 7836-7846.
107. Cígler, P.; Král, V.; Kožíšek, M.; Konvalinka, J.; Mirsky, V.: "Anomalous adsorptive properties of HIV protease: Indication of two-dimensional crystallization?" Colloids and Surfaces B: Biointerfaces 2008, 64, 145-149.
106. Král, V.; Mader, P.; Collard, R.; Fábry, M.; Hořejší, M.; Řezáčová, P.; Kožíšek, M.; Závada, J.; Sedláček, J.; Rulíšek, M.; Brynda, J.: "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations" Proteins 2008, 71, 1275-1287.
105. Hoffman, H.E.; Jirásková, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.: "Recombinant human serine racemase: Enzymologic characterization and comparison with its mouse ortholog" Protein Expr Purif. 2008, 63, 62-67.
104. Grantz Šašková, K.; Kožíšek, M.; Lepšík, M.; Brynda, J.; Řezáčová, P.; Václavíková, J.; Kagan, R.; Machala, L.; Konvalinka, J.: "Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility to HIV Protease Inhibitor Lopinavir" Protein Sci. 2008, 17, 1555-1564.
103. Kožíšek, M.; Cígler, P.; Lepšík, M.; Fanfrlík, J.; Řezáčová, P.; Brynda, J.; Pokorná, J.; Plešek, J.; Gruner, B.; Grantz Šašková, K.; Václavíková, J.; Král, V.; Konvalinka, J.: "Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming, Antiviral Resistance" J. Med. Chem. 2008, 51, 4839-4843.
102. Kožíšek, M.; Grantz Šašková, K.; Řezáčová, P.; Maarseveen, N.; De Jong, D.; Boucher, C.A.; Kagan, R.M.; Nijhuis, M.N.; Konvalinka, J.: "Ninety Nine is Not Enough: Molecular Characterization of Inhibitor Resistant HIV-1 Protease Mutants with Insertions in the Flap Region" J. Virol. 2008, 82, 5869-5878.
101. Wildová, M.; Hadravová, R.; Štokrová, J.; Křížová, I.; Ruml, T.; Hunter, E.; Pichová, I.; Rumlová, M.: "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" Virology 2008, 380, 157-163.
100. Macek, P.; Žídek, L.; Rumlová, M.; Pichová, I.; Sklenář, V.: "1H, 13C, and 15N resonance assignment of the N-terminal domain of Mason-Pfizer monkey virus capsid protein, CA 1-140" Biomol NMR Assign 2008, 2, 43-45.
99. Gammon, D. B.; Snoeck, R.; Fiten, P.; Krečmerová, H.; Holý, A.; De Clercq, E.; Opdenakker, G.; Evans, D. H.; Andrei, G.: "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" J. Virol. 2008, 82, 12520-12534.
98. Renders, M.; Lievrouw, R.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic polymerization of phosphonate nucleosides" ChemBioChem 2008, 9, 2883-2888.
97. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
96. Naesens, L.; Andrei, G.; Votruba, I.; Krečmerová, M.; Holý, A.; Neyts, J.; De Clercq, E.; Snoeck, R.: "Intracellular metabolism of the new antiviral compound, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine" Biochem. Pharmacol. 2008, 76, 997-1005.
95. Votruba, I.; Otová, B.; Holý, A.: "Acyklické nukleosidfosfonáty jako potenciální antineoplastika" Čas. Lék. čes. 2008, 147, 471-477.
94. Kuchař, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines" Tetrahedron 2008, 64, 10355-10364.
93. Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665-678.
92. Dračínský, M.; Krečmerová, M.; Holý, A.: "Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy" Bioorg. Med. Chem. 2008, 16, 6778-6782.
91. Kuchař, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations" Org. Biomol. Chem. 2008, 6, 2377-2387.
90. Turek, P.; Hocek, M.; Pohl, R.; Klepetářová, B.; Kotora, M.: "Cobalt-Induced Synthesis of 6-(Pyridin-2-yl)purines by Microwave-Enhanced [2+2+2] Cyclotrimerization" Eur. J. Org. Chem. 2008, 3335-3343.
89. Bambuch, V.; Pohl, R.; Hocek, M.: "Synthesis of 6-(4,5-Dihydrofuran-2-yl)- and 6-(Tetrahydrofuran-2-yl)purine Bases and Nucleosides" Eur. J. Org. Chem. 2008, 2783-2788.
88. Novák, P.; Číhalová, S.; Otmar, M.; Hocek, M.; Kotora, M.: "Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues" Tetrahedron 2008, 64, 5200-5207.
87. Šilhár, P.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides" Bioorg. Med. Chem. 2008, 16, 2329-2366.
86. Schinkmanová, M.; Votruba, I.; Shibata, R.; Han, B.; Liu, X.; Cihlar, T.; Holý, A.: "Human N6-Methyl-AMP/dAMP Aminohydrolase aminohydrolase (abacavir 5'-monophosphate deaminase) is capable of metabolizing N6-substituted purine acyclic nucleoside phosphonates" Collect. Czech. Chem. Commun. 2008, 73, 275-291.
85. Hasník, Z.; Šilhár, P.; Hocek, M.: "Hydroxymethylations of Aryl Halides by Pd-Catalyzed Cross-Couplings with (Benzoyloxy)methylzinc Iodide – Scope and Limitations of the Reaction" Synlett 2008, 543–546.
84. Hájek, M.; Votruba, I.; Holý, A.; Krečmerová, M.; Tloušťová, E.: "Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells" Biochem. Pharmacol. 2008, 75, 965-972.
83. Pomeisl, K.; Holý, A.; Votruba, I.; Pohl, R.: "Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase" Bioorg. Med. Chem. Lett. 2008, 18, 1364-1367.
82. Rovenská, M.; Hlouchová, K.; Šácha, P.; Mlčochová, P.; Horák, V.; Zámečník, J.; Bařinka, C.; Konvalinka, J.: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs" Prostate 2008, 68, 171-182.
81. Bařinka, C.; Hlouchová, K.; Rovenská, M.; Majer, P.; Dauter, M.; Hin, N.; Ko, Y.-S.; Tsukamoto, T.; Slusher, B.S., Konvalinka, J.; Lubkowski, J.: "Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs" J. Mol. Biol. 2008, 376, 1438-1450.
80. Kuchař, M.; Hocek, M.; Pohl, R.; Votruba, I.; Shih, I.; Mabery, E.; Mackman, R.: "Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides" Bioorg. Med. Chem. 2008, 16, 1400–1424.